(1) 非天然氨基酸与多肽的合成及应用研究

利用合成化学的手段模拟自然界中存在的酶学反应亚博网APP手机版_登录网页亚博网APP手机版_登录网页，设计及合成新型催化剂或者配体，克服酶催化中面临的诸多难题亚博网APP手机版_登录网页，如底物普适性非常有限亚博网APP手机版_登录网页，反应对酸碱，温度等极度敏感亚博网APP手机版_登录网页，蛋白不稳定等难题亚博网APP手机版_登录网页，实现传统酶化学中无法完成的反应?；谝椎玫陌被峄蛘咭子诤铣傻亩嚯?亚博网APP手机版_登录网页，合成高附加值的非天然氨基酸或者多肽化合物亚博网APP手机版_登录网页亚博网APP手机版_登录网页。

(2) 生物相容性反应地开发

生物分子往往具有非常复杂的结构亚博网APP手机版_登录网页亚博网APP手机版_登录网页，生命体内的反应往往是在水相和生理环境条件下发生反应。我们小组打算发展生物相容性反应亚博网APP手机版_登录网页亚博网APP手机版_登录网页，利用光催化的策略亚博网APP手机版_登录网页亚博网APP手机版_登录网页，发展可以适用于复杂多肽和蛋白质高选择性反应亚博网APP手机版_登录网页，可以得到非天然蛋白质类生物分子。将合成化学与合成生物学组合起来亚博网APP手机版_登录网页亚博网APP手机版_登录网页，必将极大地加速新药的研发亚博网APP手机版_登录网页。

本课题组长期诚聘副研究员亚博网APP手机版_登录网页，博士后亚博网APP手机版_登录网页，研究助理，硕博连读研究生及联合培养研究生等青年才俊亚博网APP手机版_登录网页亚博网APP手机版_登录网页，有意者请直接与课题组长联系。

 Before joining ShanghaiTech University (Selected Publications)：

1.    Gao, D.-W.; Jamieson, C. S.; Wang, G.; Yan, Y.; Zhou, J.; Houk, K. N.; Tang, Y. A Polyketide Cyclase That Forms Medium-ring Lactones. (Submitted).

2.    Gao, D.-W.^?; Gao, Y.^?; Shao, H.; Qiao, T.-Z.; Wang, X.; Sanchez, B.; Chen, J. S.; Liu, P.; Engle, K. M. Cascade CuH-Catalyzed Conversion of Alkynes to Enantioenriched 1,1-Disubstituted Products. Nat.Catal. 2020, 3, 23-29. (^?Authors contributed equally).

3.    Gao, D.-W.; Vinogradova, E. V.; Nimmagadda, S. K.; Medina, J. M.; Xiao, Y.; Suciu, R. M.; Cravatt, B. M.; Engle, K. M. Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes. J. Am. Chem. Soc. 2018, 140, 8069-8073. (Top 1“Most Read Article”in June 2018.; Featured in Organic Chemistry Highlights.)

4.    Gao, D.-W.; Xiao, Y.; Liu, M.; Liu, Z.; Karunananda, M. K.; Chen, J. S.; Engle, K. M. Catalytic, Enantioselective Synthesis of Allenyl Boronates. ACS Catal. 2018, 8, 3650–3654. (Highlighted in the Jan/Feb ChemRxiv Round-up; Highlighted in Synfacts 2018, 14, 734.; Featured in Organic Chemistry Highlights on October 22, 2018.; One of the “Most Read Articles” in March 2018.)

5.   Gao, D.-W.; Gu, Q.; Zheng, C.; You, S.-L. Synthesis of Planar Chiral Ferrocenes via Transition-Metal-Catalyzed Direct C-H Bond Functionalization. Acc. Chem. Res. 2017, 50, 351-365.

6.    Gao, D.-W.; Gu, Y.; Wang, S.-B.; Gu, Q.; You, S.-L. Pd(0)-Catalyzed Asymmetric C–H Alkenylation for Efficient Synthesis of Planar Chiral Ferrocenes. Organometallics 2016, 35, 3227-3233.

7.   Gao, D.-W.; Gu, Q.; You, S.-L. An Enantioselective Oxidative C?H/C?H Cross-Coupling Reaction: Highly Efficient Method To Prepare Planar Chiral Ferrocenes. J. Am. Chem. Soc. 2016, 138, 2544-2547. (Highlighted by Chemical & Engineering News on March 14, 2016.)

8.  Gao, D.-W.; Gu, Q.; You, S.-L. Pd(II)-Catalyzed Intermolecular Direct C?H Bond Iodination: An Efficient Approach toward the Synthesis of Axially Chiral Compounds via Kinetic Resolution. ACS Catal. 2014, 4, 2741-2745. (One of the “Most Read Articles”in July 2014.; Highlighted in ACS Catal. Spotlights.)

9.   Gao, D.-W.; Yin, Q.; Gu, Q.; You, S.-L. Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C?H Bond Arylation. J. Am. Chem. Soc. 2014, 136, 4841-4844. (Highlighted by Synfacts 2014, 10, 597.)

10.  Gao, D.-W.; Shi, Y.-C.; Gu, Q.; Zhao, Z.-L.; You, S.-L. Enantioselective Synthesis of Planar Chiral Ferrocenes via Palladium-Catalyzed Direct Coupling with Arylboronic Acids. J. Am. Chem. Soc. 2013, 135, 86-89. (Highlighted by Synfacts 2013, 9, 0417.; Highlighted by Chin. J. Org. Chem. 2013, 33, 654.)

       BOOK CHAPTER

(1) Gao, D.-W.; Zheng, J.; Ye. K.-Y.; Zheng. C.; You, S.-L. Asymmetric Functionalization of C–H Bonds via a Transient Carbon-Metal (C–M) Species. in Asymmetric Functionalization of C–H Bonds, You, S.-L., Ed., Royal Society of Chemistry 2015, pp.141-213.

PATENTS

(1) You, S.-L.; Gao, D.-W.; Gu, Q. A Kind of Planar Chiral Ferrocene Compounds, Synthetic Methods and Their Applications. The Number of Patent (ZL201510757648.8).

(2) You, S.-L.; Gao, D.-W.; Yin, Q.; Gu, Q. The Preparation of Planar Chiral Ferrocene Derivatives and Their Applications. The Number of Patent (ZL201410040306.X).

(3) You, S.-L.; Gu, Q.; Gao, D.-W.; Shi, Y.-C.; Zhao, Z.-L. The Synthesis of New Kind of Planar Chiral Ferrocene Compounds and Their Applications. The Number of  Patent (ZL201210489246.0).